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- Title
Clinical course of patients with breast cancer with ten or more positive nodes who were treated with doxorubicin-containing adjuvant therapy.
- Authors
Buzdar, Aman U.; Kau, Shu-Wan; Hortobagyi, Gabriel N.; Ames, Frederick C.; Holmes, Frankie A.; Fraschini, Giuseppe; Hug, Verena; Theriault, Richard L.; McNeese, Marsha D.; Singletary, S. Eva; Buzdar, A U; Kau, S W; Hortobagyi, G N; Ames, F C; Holmes, F A; Fraschini, G; Hug, V; Theriault, R L; McNeese, M D; Singletary, S E
- Abstract
Between 1974 and 1986, 283 patients with ten or more positive nodes were treated in four prospective trials using doxorubicin-containing adjuvant chemotherapy. At a median follow-up of 92 months, 182 patients had had a recurrence, and 158 died. An estimated 41% and 37% were disease-free at 5 and 7 years, respectively. Patients with ten positive nodes had a significantly better disease-free survival than those with more than ten such nodes (P = 0.04). The disease-free survival rate and overall survival rate were not influenced by the estrogen receptor status of the tumor, patient age, or disease stage. Long-term data on a large number of patients treated at this institute showed the natural history of this subgroup of patients. Approximately 30% of patient survived disease-free at 10 years after treatment with the systemic therapies used in these protocols. Newer approaches are needed to alter the prognosis of this subgroup of patients further.
- Publication
Cancer (0008543X), 1992, Vol 69, Issue 2, p448
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19920115)69:2<448::AID-CNCR2820690229>3.0.CO;2-K