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- Title
Relationship between T Cell Activation and CD4<sup>+</sup> T Cell Count in HIV-Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy.
- Authors
Hunt, Peter W.; Brenchley, Jason; Sinclair, Elizabeth; McCune, Joseph M.; Roland, Michelle; Page-Shafer, Kimberly; Hsue, Priscilla; Emu, Brinda; Krone, Melissa; Lampiris, Harry; Douek, Daniel; Martin, Jeffrey N.; Deeks, Steven G.
- Abstract
Background. Although untreated human immunodeficiency virus (HIV)-infected patients maintaining undetectable plasma HIV RNA levels (elite controllers) have high HIV-specific immune responses, it is unclear whether they experience abnormal levels of T cell activation, potentially contributing to immunodeficiency. Methods. We compared percentages of activated (CD38+HLA-DR+) T cells between 30 elite controllers, 47 HIV-uninfected individuals, 187 HIV-infected individuals with undetectable viremia receiving antiretroviral therapy (antiretroviral therapy suppressed), and 66 untreated HIV-infected individuals with detectable viremia. Because mucosal translocation of bacterial products may contribute to T cell activation in HIV infection, we also measured plasma lipopolysaccharide (LPS) levels. Results. Although the median CD4+ cell count in controllers was 727 cells/mm3, 3 (10%) had CD4+ cell counts <350 cells/mm3 and 2 (7%) had acquired immunodeficiency syndrome. Controllers had higher CD4+ and CD8+ cell activation levels (P < .001 for both) than HIV-negative subjects and higher CD8+ cell activation levels than the antiretroviral therapy suppressed (P = .048). In controllers, higher CD4+ and CD8+ T cell activation was associated with lower CD4+ cell counts (P = .009 and P .047). Controllers had higher LPS levels than HIV-negative subjects (P < .001), and in controllers higher LPS level was associated with higher CD8+ T cell activation (P = .039). Conclusion. HIV controllers have abnormally high T cell activation levels, which may contribute to progressive CD4+ T cell loss even without measurable viremia.
- Subjects
T cells; HIV-positive persons; IMMUNODEFICIENCY; ANTIRETROVIRAL agents; AIDS; ENDOTOXINS
- Publication
Journal of Infectious Diseases, 2008, Vol 197, Issue 1, p126
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/524143