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- Title
Special FX: Harnessing the Farnesoid-X-Receptor to Control Bile Acid Synthesis.
- Authors
Fiorucci, Stefano; Distrutti, Eleonora; Biagioli, Michele
- Abstract
Nevertheless, the two diseases respond well to treatment with the exogenous bile acid CA, 5-15 mg/kg, which has been approved for treatment of inborn errors of bile acid metabolism in Western countries, though CDCA and a combination of CDCA and UDCA have also been proven effective in reducing the production of atypical bile acids [[6]]. The farnesoid-X-receptor (FXR) is the principal bile acid sensor in mammals that is activated in response to increased concentrations of CDCA and CA, which activate FXR at significantly different EC SB 50 sb : ( 10 µM for CDCA and > 50 µM for CA). 1 Regulation of bile acid synthesis by FXR and its target genes SHP and GFG19. a Schematic of bile acid synthesis. Since CYP7A1 is important for bile acid homeostasis, it is likely that FXR/FGF19/FGFR4 signaling represents the major physiological mechanism for the negative feedback regulation of bile acid synthesis.
- Subjects
BILE acids; HYDROXYCHOLESTEROLS; FARNESOID X receptor; CELL receptors; FIBROBLAST growth factors
- Publication
Digestive Diseases & Sciences, 2021, Vol 66, Issue 11, p3668
- ISSN
0163-2116
- Publication type
Editorial
- DOI
10.1007/s10620-021-06840-7