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- Title
Risk of ocular complications following radiation therapy in patients with nasopharyngeal carcinoma.
- Authors
Lin, Kuen‐Tze; Lee, Shih‐Yu; Liu, Shao‐Cheng; Tsao, Chih‐Cheng; Hsu, Sheng‐Der; Chien, Wu‐Chien; Chung, Chi‐Hsiang; Chang, Wei‐Kuo; Chen, Yuan‐Wu; Lin, Chun‐Shu; Lin, Kuen-Tze; Lee, Shih-Yu; Liu, Shao-Cheng; Tsao, Chih-Cheng; Hsu, Sheng-Der; Chien, Wu-Chien; Chung, Chi-Hsiang; Chang, Wei-Kuo; Chen, Yuan-Wu; Lin, Chun-Shu
- Abstract
<bold>Objective: </bold>To examine the risk of ocular complications following radiotherapy in patients with nasopharyngeal carcinoma (NPC).<bold>Methods: </bold>We adopted 1:1 propensity score matching and identified an NPC cohort (n = 736) and a comparison cohort (n = 736) that comprised non-NPC head and neck cancer patients who received radiotherapy in the National Health Insurance Research Database from 1997 to 2010. The follow-up period was terminated upon developing ocular complications (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM]360-379) or on December 31, 2010.<bold>Results: </bold>After adjusting for the confounding factors of the study, the NPC cohort had a higher adjusted hazard ratio (HR) for developing ocular complications than the comparison cohort (adjusted HR = 2.786, 95% confidence interval [CI] = 1.805-4.112, P < 0.001). The NPC cohort was associated with a significantly higher risk of developing ocular complications compared with the comparison cohort within 12 and after 24 months of follow-up (P < 0.05). The most common associated ocular complications were optic nerve disorder and retinopathy.<bold>Conclusions: </bold>Patients with NPC might be at higher risk of developing ocular complications after radiotherapy than non-NPC head and neck cancer patients in Taiwan. Either further investigation or routine assessments by ophthalmological physician is recommended.<bold>Level Of Evidence: </bold>NA Laryngoscope, 130:1270-1277, 2020.
- Subjects
TAIWAN; RADIOTHERAPY; PROPENSITY score matching; HEAD &; neck cancer; CARCINOMA; OPTIC nerve; NOSOLOGY; NASOPHARYNX tumors; RETROSPECTIVE studies; RISK assessment; RADIATION injuries; EYE diseases
- Publication
Laryngoscope, 2020, Vol 130, Issue 5, p1270
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.28254