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- Title
Automated Indentation Mapping of Vocal Fold Structure and Cover Properties Across Species.
- Authors
Dion, Gregory R.; Lavoie, Jean‐Francois; Coelho, Paulo; Amin, Milan R.; Branski, Ryan C.; Lavoie, Jean-Francois
- Abstract
<bold>Objectives/hypothesis: </bold>Various animal models have been employed to investigate vocal fold (VF) and phonatory function. However, biomechanical testing techniques to characterize vocal fold structural properties vary and have not compared critical properties across species. We adapted a nondestructive, automated indentation mapping technique to simultaneously quantify VF structural properties (VF cover layer and intact VF) in commonly used species based on the hypothesis that VF biomechanical properties are largely preserved across species.<bold>Study Design: </bold>Ex vivo animal model.<bold>Methods: </bold>Canine, leporine, and swine larynges (n = 4 each) were sagittally bisected, measured, and subjected to normal indentation mapping (indentation at 0.3 mm; 1.2 mm/s) with a 2-mm spherical indenter to quantify normal force along the VF cover layer, structural stiffness, and displacement at 0.8 mN; two-dimensional maps of the free VF edge through the conus elasticus were created for these characterizations.<bold>Results: </bold>Structural stiffness was 7.79 gf/mm (0.15-74.55) for leporine, 2.48 gf/mm (0.20-41.75) for canine, and 1.45 gf (0.56-4.56) for swine. For each species, the lowest values were along the free VF edge (mean ± standard deviation; leporine: 0.40 ± 0.21 gf/mm, canine: 1.14 ± 0.49 gf/mm, swine: 0.89 ± 0.28 gf/mm). Similar results were obtained for the cover layer normal force at 0.3 mm. On the free VF edge, mean (standard deviation) displacement at 0.08 gf was 0.14 mm (0.05) in leporine, 0.11 mm (0.03) in canine, and 0.10 mm (0.02) in swine.<bold>Conclusions: </bold>Automated indentation mapping yielded reproducible biomechanical property measurement of the VF cover and intact VF. Divergent VF structural properties across canine, swine, and leporine species were observed.<bold>Level Of Evidence: </bold>NA Laryngoscope, 129:E26-E31, 2019.
- Subjects
VOCAL cords; LABORATORY animals; STANDARD deviations; VOICE disorders; CANIDAE; VOCAL cord physiology; ANIMALS; BIOLOGICAL models; DOGS; ELASTICITY; IMMUNITY; KINEMATICS; RABBITS; RESEARCH evaluation; SWINE; HUMAN voice; IN vitro studies
- Publication
Laryngoscope, 2019, Vol 129, Issue 1, pE26
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.27341