The article focuses on the efficiency of tetracycline as an antibiotic resistance. It states that tetracycline antibiotics possess a well-established chemical properties and breakdown products, including epimerization at C4 and dehydration at C6 generating aromatization of the ring C. It notes that such antibiotic often occur by oxidative breakdown which is catalyzed by flavin-dependent monooxygenases, and by protection of the target ribosome by immunity proteins.