We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mycousfurans A and B, Antibacterial Usnic Acid Congeners from the Fungus Mycosphaerella sp., Isolated from a Marine Sediment.
- Authors
Lee, Jihye; Lee, Jusung; Kim, Geum Jin; Yang, Inho; Wang, Weihong; Nam, Joo-Won; Choi, Hyukjae; Nam, Sang-Jip; Kang, Heonjoong
- Abstract
Mycousfurans (1 and 2), two new usnic acid congeners, along with (−)-mycousnine (3), (−)-placodiolic acid (4), and (+)-usnic acid (5), were isolated using high-performance liquid chromatography-ultraviolet (HPLC-UV)-guided fractionation of extracts of Mycosphaerella sp. isolated from a marine sediment. The planar structures of 1 and 2 were elucidated using 1D and 2D NMR spectra. The relative configurations of the stereogenic carbons of 1 and 2 were established via analysis of their nuclear Overhauser spectroscopy (NOESY) spectra, and their absolute configurations were determined using a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1 and 2 were found to have antibacterial activity, showing moderate activity against Kocuria rhizophila and Staphylococcus aureus.
- Subjects
MARINE sediments; MYCOSPHAERELLA; NUCLEAR spectroscopy; CIRCULAR dichroism; FUNGI
- Publication
Marine Drugs, 2019, Vol 17, Issue 7, p422
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md17070422