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- Title
Molecular Targets of Active Anticancer Compounds Derived from Marine Sources.
- Authors
Song, Xiaoping; Xiong, Ying; Qi, Xin; Tang, Wei; Dai, Jiajia; Gu, Qianqun; Li, Jing
- Abstract
Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone deacetylase, the ubiquitin-proteasome system, and so on. Specific emphasis of this review paper is to provide information on the optimization of new target compounds for future research and development of anticancer drugs, based on the identification of structures of these target molecules and parallel compounds.
- Subjects
ANTINEOPLASTIC agents; PUBLIC health; MARINE biotechnology; DNA topoisomerases; PROTEIN kinase C
- Publication
Marine Drugs, 2018, Vol 16, Issue 5, p175
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md16050175