We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Influence of a family history of type 2 diabetes, demographic and clinical data on carotid intimamedia thickness in patients with type 1 diabetes: a cross-sectional study.
- Authors
Andrade de Junior, Carlos Roberto Moraes; Clemente Silva, Eliete Leão; Bevilaqua da Matta, Maria de Fátima; Castier, Marcia Bueno; Garcia Rosa, Maria Luiza; Brito Gomes, Marília de
- Abstract
Background Intima-media thickness (IMT) of the common carotid artery is a surrogate end point of cardiovascular disease (CVD). Identifying the factors associated with a higher IMT may contribute to the identification of subjects with higher CVD risk. Our objective was to compare the common carotid IMT of type 1 diabetes patients to healthy control subjects. The secondary objective was to determine factors associated with a higher carotid IMT. Methods We conducted a cross-sectional study between March 2009 and October 2013, comprising 127 type 1 diabetes patients and 125 control subjects matched by age, gender and body mass index (BMI). Carotid IMT was measured using semi-automated edge detection software. Results Type 1 diabetes patients had a higher median IMT compared with control subjects (0.538, IQR: 0.500-0.607 vs 0.513 mm; IQR: 0.481-0.557, respectively p = 0.001). Women with type 1 diabetes had a higher median IMT difference compared to the control group (0.537, IQR: 0.495-0.596 vs 0.502 mm, IQR: 0.472-0.543, respectively p = 0.003) than did men with type 1 diabetes (0.547, IQR: 0.504-0.613 vs 0.528 mm, IQR: 0.492-0.575, respectively p = 0.2). Age and diabetes duration had an additive effect on the IMT of type 1 diabetes patients. Multivariate gamma regression model analysis showed that in type 1 diabetes patients, the IMT was associated with age (Exp (β) = 1.006, p < 0.001), duration of diabetes (Exp (β) = 1.004, p = 0.001), BMI (Exp (β) = 1.005, p = 0.021), family history of type 2 diabetes (Exp (β) = 1.044, p = 0.033), total cholesterol (Exp (β) = 0.999, p = 0.001) and creatinine clearance (Exp (β) = 1.000, p = 0.043). Conclusions Patients with type 1 diabetes have increased IMT, a marker of subclinical atherosclerosis. The CVD risk may be similar between men and women with type 1 diabetes, suggesting a loss of gender protection. Also, CVD risk may be higher in those with a family history of type 2 diabetes. Prospective studies are needed to confirm the predictive value of these findings and the causal effect between IMT and CVD in patients with type 1 diabetes.
- Subjects
DIABETES; DEMOGRAPHIC surveys; PATIENTS; CAROTID artery; REGRESSION analysis
- Publication
Cardiovascular Diabetology, 2014, Vol 13, Issue 1, p1
- ISSN
1475-2840
- Publication type
Article
- DOI
10.1186/1475-2840-13-87