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- Title
Gastrointestinal peptides in children before and after hematopoietic stem cell transplantation.
- Authors
Skoczeń, Szymon; Rej, Magdalena; Kwiecińska, Kinga; Pietrys, Danuta; Tomasik, Przemysław J.; Wójcik, Małgorzata; Strojny, Wojciech; Dłużniewska, Agnieszka; Klimasz, Katarzyna; Fijorek, Kamil; Korostyński, Michał; Piechota, Marcin; Balwierz, Walentyna
- Abstract
<bold>Background: </bold>Gastrointestinal tract function and it's integrity are controlled by a number of peptides whose secretion is influenced by severe inflammation. In stomach the main regulatory peptide is ghrelin. For upper small intestine cholecystokinin and lower small intestine glucagon-like peptide- 1 are secreted, while fibroblast growth factor-21 is secreted by several organs, including the liver, pancreas, and adipose tissue [12]. Hematopoietic stem cell transplantation causes serious mucosal damage, which can reflect on this peptides.<bold>Methods: </bold>The aim of the study was to determine fasting plasma concentrations of ghrelin, cholecystokinin, glucagon- like peptide-1, and fibroblast growth factor-21, and their gene expressions, before and 6 months after hematopoietic stem cell transplantation.27 children were studied, control group included 26 healthy children.<bold>Results: </bold>Acute graft versus host disease was diagnosed in 11 patients (41%, n = 27). Median pre-transplantation concentrations of gastrointestinal peptides, as well as their gene expressions, were significantly lower in studied group compared with the control group. Only median of fibroblast growth factor-21 concentration was near-significantly higher before stem cell transplantation than in the control group. The post-hematopoietic transplant results revealed significantly higher concentrations of the studied peptides (except fibroblast growth factor-21) and respective gene expressions as compare to pre transplant results. Median glucagone like peptide-1 concentrations were significantly decreased in patients with features of acute graft versus host disease. Moreover, negative correlation between glucagone like peptide-1 concentrations and acute graft versus host disease severity was found.<bold>Conclusions: </bold>Increased concentrations and gene expressions of gastrointestinal tract regulation peptides can be caused by stimulation of regeneration in the severe injured organ. Measurement of these parameters may be a useful method of assessment of severity of gastrointestinal tract complications of hematopoietic stem cell transplantation.
- Subjects
HEMATOPOIETIC stem cell transplantation; GRAFT versus host disease; GLUCAGON-like peptides; PEPTIDES; STEM cell transplantation; HEMATOPOIETIC stem cells; TUMOR treatment; GLUCAGON-like peptide 1; GROWTH factors; CASE-control method; GHRELIN; SEVERITY of illness index; GENES; RESEARCH funding; TUMORS; CHOLECYSTOKININ
- Publication
BMC Cancer, 2020, Vol 20, Issue 1, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-020-06790-9