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- Title
A new pathway for anaerobic biotransformation of marine toxin domoic acid.
- Authors
Du, Miaomiao; Jin, Yuan; Fan, Jingfeng; Zan, Shuaijun; Gu, Chen; Wang, Jing
- Abstract
Domoic acid (DA) is a harmful algal toxin produced by marine diatom Pseudo-nitzschia and seriously threatens ecosystem and human health. However, the current knowledge on its biotransformation behavior in coastal anaerobic environment is lacking. This study investigated the anaerobic biotransformation of DA by a new marine consortium GH1. The results demonstrated that 90% of DA (1 mg L−1) was cometabolically biotransformed under sulfate-reducing condition. A new anaerobic biotransformation pathway involving DA hydration, dehydrogenation, and C–C bond cleavage was proposed, where the conjugated double-bond of DA was interrupted, resulting in the corresponding alcohols and ketones, subsequently cleaved hydrolytically, and yielding the lower molecular weight products. Desulfovibrio and Clostridiales were markedly enriched in the anaerobic biotransformation of DA, which might jointly contribute to the elevated bacterial consortium resistance and degradation to DA. This study could deepen understanding of behavior and fate for DA in marine environments.
- Subjects
DOMOIC acid; MARINE toxins; BIOCONVERSION; ALGAL toxins; ECOSYSTEM health; DRUG resistance in bacteria
- Publication
Environmental Science & Pollution Research, 2023, Vol 30, Issue 2, p5150
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-022-22368-3