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- Title
The Impact of Pinus koraiensis Leaf Extract Consumption on Postprandial ApoB100 and Lipid Metabolism: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Participants Subjected to an Oral High-Fat Challenge.
- Authors
Park, Soo-yeon; Park, Tae gwon; Choi, Kwanyong; Kim, Kyeong Jin; Kim, Ji Yeon
- Abstract
Pinus koraiensis (PK) leaf extract, derived from Korean pine byproducts, holds promise for alleviating postprandial hyperlipidemia. In this study, we investigated the potential of PK leaf extract for modulating postprandial hyperlipidemia in adults with normal or borderline fasting triglyceride levels. In a randomized, double-blind, parallel design, 70 subjects were randomly assigned to either the placebo or PK group for 4 weeks. After 4 weeks of consuming PK leaf extract, the results indicated a trend toward decreased serum apolipoprotein B-100 (ApoB100) levels 2 h after a high-fat challenge. Furthermore, significant improvements were observed in the incremental area under the curve (iAUC) at 0–4 h and 2–4 h compared to baseline, particularly among individuals with a higher body weight (>61.35 kg) and daily caloric intake (>1276.5 kcal). Based on these findings, PK leaf extract may have beneficial effects on postprandial lipoprotein metabolism, especially among individuals with a relatively high body weight and caloric intake.
- Subjects
HYPERLIPIDEMIA; FOOD consumption; PLACEBOS; LIPID metabolism disorders; PATIENT safety; ANTILIPEMIC agents; RESEARCH funding; STATISTICAL sampling; BLIND experiment; BODY weight; BLOOD collection; RANDOMIZED controlled trials; DESCRIPTIVE statistics; LIPOPROTEINS; DIETARY fats; PLANT extracts; APOLIPOPROTEINS; DRUG efficacy; GENETIC disorders; LEAVES; TRIGLYCERIDES; COMPARATIVE studies; FASTING; ADULTS
- Publication
Nutrients, 2024, Vol 16, Issue 17, p2864
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16172864