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- Title
The Mechanism by Which Pereskia aculeata Mill. Regulates Ferroptosis and Interferes with Colon Cancer Based on Network Pharmacology.
- Authors
Kaifei LIU; Yingyuan QIN; Linhao LIU; Ye CHU; Huanjin HUANG; Jingwei LUO; Xiaolong CHEN; Yang YANG; Yifei CHEN
- Abstract
[Objectives] The paper was to investigate the mechanism by which Pereskia aculeata Mill, regulates ferroptosis and interferes with colon cancer using network pharmacology. [Methods] The effect of P. aculeata on HCT116 cells was observed by examining cell morphology. The intersection of P. aculeata, colon cancer, and ferroptosis targets was determined using the Venny 2.1.0 online platform. DAVID database was used to perform GO and KEGG enrichment analyses. Cytoscape_v3.10. 0 was used for network mapping and PPI analysis. [Results] The observation of cell morphology indicated that P. aculeata suppressed the growth of HCT116 cells. GO and KEGG analysis identified 67 genes involved in potential pathways, including the MAPK signaling pathway and Apoptosis, 18 of which were located on the MAPK pathway. After conducting PPI visualization analysis and ranking based on Degree values, we identified TP53, TNF, EGFR, MAPK14, and AKT1 as the top five targets with the highest Degree values. [Conclusions] P. aculeata may activate thep53 gene through the MAPK signaling pathway, inducing ferroptosis and ultimately resulting in tumor cell death.
- Subjects
COLON cancer; CELL morphology; MITOGEN-activated protein kinases; CELLULAR signal transduction; CELL death
- Publication
Medicinal Plant, 2024, Vol 15, Issue 2, p26
- ISSN
2152-3924
- Publication type
Article
- DOI
10.19600/j.cnki.issn2152-3924.2024.02.007