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- Title
A Randomized Comparison of Postprandial Glucose Excursion Using Inhaled Insulin Versus Rapid-Acting Analog Insulin in Adults With Type 1 Diabetes Using Multiple Daily Injections of Insulin or Automated Insulin Delivery.
- Authors
Hirsch, Irl B.; Beck, Roy W.; Marak, Martin Chase; Calhoun, Peter; Mottalib, Adham; Salhin, Amna; Manessis, Anastasios; Coviello, Andrea D.; Bhargava, Anuj; Thorsell, Ashley; Atakov Castillo, Astrid; Bode, Bruce W.; Levister, Camilla; Levy, Carol J.; Donahue, Cassandra; Cordero, Christian; Beatson, Christie; Langel, Christine R.; Jacobson, Christopher; Kurek, Corey
- Abstract
OBJECTIVE: To compare postprandial glucose excursions following a bolus with inhaled technosphere insulin (TI) or subcutaneous rapid-acting analog (RAA) insulin. RESEARCH DESIGN AND METHODS: A meal challenge was completed by 122 adults with type 1 diabetes who were using multiple daily injections (MDI), a nonautomated pump, or automated insulin delivery (AID) and who were randomized to bolus with their usual RAA insulin (n = 61) or TI (n = 61). RESULTS: The primary outcome, the treatment group difference in area under the curve for glucose >180 mg/dL over 2 h, was less with TI versus RAA (adjusted difference −12 mg/dL, 95% CI −22 to −2, P = 0.02). With TI, the glucose excursion was smaller (P = 0.01), peak glucose lower (P = 0.01), and time to peak glucose shorter (P = 0.006). Blood glucose <70 mg/dL occurred in one participant in each group. CONCLUSIONS: Postmeal glucose excursion was smaller with TI than with RAA insulin in a cohort that included both AID and MDI users.
- Subjects
INSULIN derivatives; TYPE 1 diabetes; BLOOD sugar; INSULIN therapy; INSULIN
- Publication
Diabetes Care, 2024, Vol 47, Issue 9, p1682
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc24-0838