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- Title
Nanomedicines for Dry Eye Syndrome: Targeting Oxidative Stress with Modern Nanomaterial Strategies.
- Authors
Krawczyk, Aleksandra; Stadler, Sara Marta; Strzalka-Mrozik, Barbara
- Abstract
Dry eye syndrome (DES) is a dynamic, chronic disease of the ocular surface and ocular appendages caused by inflammation. The most common symptoms include redness, itching, and blurred vision, resulting from dysfunction of the meibomian glands and impaired tear-film production. Factors contributing to the development of DES include environmental elements, such as UV radiation, and internal elements, such as hormonal imbalances. These factors increase oxidative stress, which exacerbates inflammation on the surface of the eye and accelerates the development of DES. In recent years, the incidence of DES has risen, leading to a greater need to develop effective treatments. Current treatments for dry eye are limited and primarily focus on alleviating individual symptoms, such as reducing inflammation of the ocular surface. However, it is crucial to understand the pathomechanism of the disease and tailor treatment to address the underlying causes to achieve the best possible therapeutic outcomes. Therefore, in this review, we analyzed the impact of oxidative stress on the development of DES to gain a better understanding of its pathomechanism and examined recently developed nanosystems that allow drugs to be delivered directly to the disease site.
- Subjects
DRY eye syndromes; TREATMENT effectiveness; MEIBOMIAN glands; DRUG delivery systems; OXIDATIVE stress
- Publication
Molecules, 2024, Vol 29, Issue 16, p3732
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29163732