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- Title
Crizotinib-induced toxicity in an experimental rat model.
- Authors
Gumusay, Ozge; Esendagli-Yilmaz, Guldal; Uner, Aytug; Cetin, Bulent; Buyukberber, Suleyman; Benekli, Mustafa; Ilhan, Mustafa; Coskun, Ugur; Gulbahar, Ozlem; Ozet, Ahmet
- Abstract
Aim: The aim of the present study was to evaluate the effect of crizotinib on visceral organs in an experimental rat model. Methods: Eighteen Wistar albino rats were divided into three groups: experimental toxicity was induced with crizotinib (10 mg/kg) administered for 28 days (Group 1), 42 days (Group 2) orally by gavage. Control group received only distilled water. Rats in Group 1 and Group 2 were sacrificed after the collection of blood and tissue samples on the 28th and 42nd days, respectively. Results: Subjects in Group 1 and Group 2 had abnormal histology mainly in lung and liver. There were intraalveolar hemorrhage in lungs; mild portal inflammation, perivenular focal and confluent necrosis in liver; inflammatory reaction in renal pelvis and periureteral areas, and focal pancreatitis in pancreas. Conclusion: This study is the first to evaluate the histopathological features of toxicity of crizotinib in a rat model.
- Subjects
CRIZOTINIB; TOXICITY testing; PULMONARY alveolar proteinosis; LUNG cancer; LIVER necrosis; LABORATORY mice
- Publication
Wiener Klinische Wochenschrift, 2016, Vol 128, Issue 11/12, p435
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-016-0984-y