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- Title
An AIE‐Active Conjugated Polymer with High ROS‐Generation Ability and Biocompatibility for Efficient Photodynamic Therapy of Bacterial Infections.
- Authors
Zhou, Taotao; Hu, Rong; Wang, Lirong; Qiu, Yanping; Zhang, Guiquan; Deng, Qiyun; Zhang, Haiyan; Yin, Pingan; Situ, Bo; Zhan, Chunlie; Qin, Anjun; Tang, Ben Zhong
- Abstract
New, biocompatible materials with favorable antibacterial activity are highly desirable. In this work, we develop a unique conjugated polymer featuring aggregation‐induced emission (AIE) for reliable bacterial eradication. Thanks to the AIE and donor‐π‐acceptor structure, this polymer shows a high reactive oxygen species (ROS)‐generation ability compared to a low‐mass model compound and the common photosensitizer Chlorin E6. Moreover, the selective binding of pathogenic microorganisms over mammalian cells was found, demonstrating its biocompatibility. The effective growth inhibition of bacteria upon polymer treatment under light irradiation was validated in vitro and in vivo. Notably, the recovery from infection after treatment with our polymer is faster than that with cefalotin. Thus, this polymer holds great promise in fighting against bacteria‐related infections in practical applications.
- Subjects
PHOTODYNAMIC therapy; BACTERIAL diseases; BIOMEDICAL materials; POLYMERS; BIOCOMPATIBILITY; CONJUGATED polymers
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 25, p10038
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201916704