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- Title
Palladium‐Catalysed C(sp<sup>3</sup>)−H Glycosylation for the Synthesis of C‐Alkyl Glycoamino Acids.
- Authors
Liu, Yichu; Wang, Yibing; Dai, Wenhao; Huang, Wei; Li, Yingxia; Liu, Hong
- Abstract
We have developed a highly efficient and practical approach for palladium‐catalyzed trifluoroacetate‐promoted N‐quinolylcarboxamide‐directed glycosylation of inert β‐C(sp3)−H bonds of N‐phthaloyl α‐amino acids with glycals under mild conditions. For the first time, C(sp3)−H activation for glycosylation was achieved to build C‐alkyl glycosides. This method facilitates the synthesis of various β‐substituted C‐alkyl glycoamino acids and offers a tool for glycopeptide synthesis.
- Subjects
ACIDS; GLYCOSIDES; GLYCOSYLATION; PALLADIUM
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 9, p3519
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201914184