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- Title
Copper‐Catalyzed Ring Opening of Benzofurans and an Enantioselective Hydroamination Cascade.
- Authors
Xu‐Xu, Qing‐Feng; Liu, Qiang‐Qiang; Zhang, Xiao; You, Shu‐Li
- Abstract
A copper(II) acetate/(R)‐DTBM‐SEGPHOS‐catalyzed ring opening of benzofurans and enantioselective hydroamination cascade with dimethoxymethylsilane (DMMS) and hydroxylamine esters is described. Starting from readily available substituted benzofurans, a series of chiral N,N‐dibenzylaminophenols, which are of high interest in pharmaceutical chemistry, were obtained with excellent enantioselectivities (up to 66 % yield, 94 % ee).
- Subjects
BENZOFURANS; HYDROAMINATION; COPPER catalysts; ENANTIOSELECTIVE catalysis; PHARMACEUTICAL chemistry
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 46, p15424
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201809003