We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mussel-Inspired Surface-Imprinted Sensors for Potentiometric Label-Free Detection of Biological Species.
- Authors
Liang, Rongning; Ding, Jiawang; Gao, Shengshuai; Qin, Wei
- Abstract
Using sensors to quantify clinically relevant biological species has emerged as a fascinating research field due to their potential to revolutionize clinical diagnosis and therapeutic monitoring. Taking advantage of the wide utility in clinical analysis and low cost of potentiometric ion sensors, we demonstrate a method to use such ion sensors to quantify bioanalytes without chemical labels. This is achieved by combination of chronopotentiometry with a mussel-inspired surface imprinting technique. The biomimetic sensing method is based on a blocking mechanism by which the recognition reaction between the surface imprinted polymer and a bioanalyte can block the current-induced ion transfer of an indicator ion, thus causing a potential change. The present method offers high sensitivity and excellent selectivity for detection of biological analytes. As models, trypsin and yeast cells can be measured at levels down to 0.03 U mL−1 and 50 CFU mL−1, respectively.
- Subjects
POTENTIOMETRY; IMPRINTED polymers; CHRONOAMPEROMETRY; MOLECULAR recognition; CHEMICAL labeling
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 24, p6937
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201701892