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- Title
Solid-State Conformational Flexibility at Work: Zipping and Unzipping within a Cyclic Peptoid Single Crystal.
- Authors
Meli, Alessandra; Macedi, Eleonora; De Riccardis, Francesco; Smith, Vincent J.; Barbour, Leonard J.; Izzo, Irene; Tedesco, Consiglia
- Abstract
A peptidomimetic compound undergoes a reversible single-crystal-to-single-crystal transformation upon guest release/uptake with the transformation involving a drastic conformational change. The extensive and reversible alteration in the solid state is connected to the formation of an unprecedented 'CH-π zipper' which can reversibly open and close (through the formation of CH-π interactions), thus allowing for guest sensing.
- Subjects
SINGLE crystals; PEPTIDOMIMETICS; SYNTHETIC proteins; CYCLIC peptides; SOLID state chemistry
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 15, p4757
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201511053