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- Title
Development of Chiral Spiro P-N-S Ligands for Iridium-Catalyzed Asymmetric Hydrogenation of β-Alkyl-β-Ketoesters.
- Authors
Bao, Deng-Hui; Wu, Hui-Ling; Liu, Chao-Lun; Xie, Jian-Hua; Zhou, Qi-Lin
- Abstract
The chiral tridentate spiro P-N-S ligands (SpiroSAP) were developed, and their iridium complexes were prepared. Introduction of a 1,3-dithiane moiety into the ligand resulted in a highly efficient chiral iridium catalyst for asymmetric hydrogenation of β-alkyl-β-ketoesters, producing chiral β-alkyl-β-hydroxyesters with excellent enantioselectivities (95-99.9 % ee) and turnover numbers of up to 355 000.
- Subjects
LIGANDS (Chemistry); ESTERS; HYDROGENATION; CATALYSIS research; IRIDIUM compounds
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 30, p8915
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201502860