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- Title
Redox-Neutral a-Allylation of Amines by Combining Palladium Catalysis and Visible-Light Photoredox Catalysis.
- Authors
Jun Xuan; Ting-Ting Zeng; Zhu-Jia Feng; Qiao-Hui Deng; Jia-Rong Chen; Liang-Qiu Lu; Wen-Jing Xiao; Alper, Howard
- Abstract
An unprecedented a-allylation of amines was achieved by combining palladium catalysis and visible-light photoredox catalysis. In this dual catalysis process, the catalytic generation of allyl radical from the corresponding π-allylpalladium intermediate was achieved without additional metal reducing reagents (redox-neutral). Various allylation products of amines were obtained in high yields through radical crosscoupling under mild reaction conditions. Moreover, the transformation was applied to the formal synthesis of 8-oxoprotoberberine derivatives which show potential anticancer properties.
- Subjects
AMINES; ALLYLATION; OXIDATION-reduction reaction; PALLADIUM catalysts; VISIBLE spectra; PHOTOCATALYSIS; PROTOBERBERINE
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 5, p1645
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201409999