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Synthesis, NMR Characterization, and Antileukemic Activity of N-Nonanoylpiperazinyl-5α-Androstane-3,17β-Diol A-Ring Derivatives.
- Published in:
- Magnetochemistry, 2021, v. 7, n. 1, p. 1, doi. 10.3390/magnetochemistry7010003
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- Publication type:
- Article
Structure Confirmation and Evaluation of a Nonsteroidal Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 10.
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- Magnetochemistry, 2018, v. 4, n. 3, p. 1, doi. 10.3390/magnetochemistry4030032
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- Publication type:
- Article
An Aminosteroid Derivative Shows Higher In Vitro and In Vivo Potencies than Gold Standard Drugs in Androgen-Dependent Prostate Cancer Models.
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- Cancers, 2023, v. 15, n. 11, p. 3033, doi. 10.3390/cancers15113033
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- Publication type:
- Article
A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models.
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- Cancers, 2021, v. 13, n. 8, p. 1841, doi. 10.3390/cancers13081841
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- Publication type:
- Article
Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models.
- Published in:
- PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0171871
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- Publication type:
- Article
Diversity-Oriented Synthesis of Spiro- and Fused Azacycles from Ketone Molecular Templates.
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- European Journal of Organic Chemistry, 2012, v. 2012, n. 28, p. 5435, doi. 10.1002/ejoc.201200852
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- Publication type:
- Article
Design, chemical synthesis, and in vitro biological evaluation of simplified estradiol–adenosine hybrids as inhibitors of 17β-hydroxysteroid dehydrogenase type 1.
- Published in:
- Canadian Journal of Chemistry, 2009, v. 87, n. 8, p. 1180, doi. 10.1139/V09-083
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- Publication type:
- Article
Detection of 5α-androst-2-en-17-one and variants: Identification of main urinary metabolites in human urine samples by GC-MS and NMR.
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- Drug Testing & Analysis, 2016, v. 8, n. 11/12, p. 1174, doi. 10.1002/dta.2105
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- Publication type:
- Article
Estrogen receptor-α mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of Cypl 7a1 (cytochrome P450, steroid 17 -hyðdroxylase/17,20 lyase) expression.
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- FASEB Journal, 2007, v. 21, n. 2, p. 586, doi. 10.1096/fj.06-6681com
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- Publication type:
- Article
A concerted, rational design of type 1 17β‐hydroxysteroid dehydrogenase inhibitors: estradiol‐adenosine hybrids with high affinity.
- Published in:
- FASEB Journal, 2002, v. 16, n. 13, p. 1, doi. 10.1096/fj.02-0026fje
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- Publication type:
- Article
Description of Chemical Synthesis, Nuclear Magnetic Resonance Characterization and Biological Activity of Estrane-Based Inhibitors/Activators of Steroidogenesis.
- Published in:
- Molecules, 2023, v. 28, n. 8, p. 3499, doi. 10.3390/molecules28083499
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- Publication type:
- Article
Chemical Synthesis and Biological Evaluation of 3-Substituted Estrone/Estradiol Derivatives as 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Acting via a Reverse Orientation of the Natural Substrate Estrone.
- Published in:
- Molecules, 2023, v. 28, n. 2, p. 632, doi. 10.3390/molecules28020632
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- Publication type:
- Article
Synthesis and Characterization of Novel Cu(II), Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.0<sup>2,7</sup>)tridecan-13-onethiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity.
- Published in:
- Molecules, 2016, v. 21, n. 5, p. 674, doi. 10.3390/molecules21050674
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- Publication type:
- Article
High Level of Esterification of Steroids to Long-Chain Fatty Acids in ZR-75-1 Human Breast Cancer Cells.
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- Annals of the New York Academy of Sciences, 1990, v. 595, n. 1, p. 422, doi. 10.1111/j.1749-6632.1990.tb34324.x
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- Publication type:
- Article
Hormonal Regulation of Estradiol 17β-Hydroxysteroid Dehydrogenase Activity in the ZR-75-1 Human Breast Cancer Cell Line.
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- Annals of the New York Academy of Sciences, 1990, v. 595, n. 1, p. 419, doi. 10.1111/j.1749-6632.1990.tb34323.x
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- Publication type:
- Article
Interactions between Estrogens, Androgens, Progestins, and Glucocorticoids in ZR-75-1 Human Breast Cancer Cells.
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- Annals of the New York Academy of Sciences, 1990, v. 595, n. 1, p. 130, doi. 10.1111/j.1749-6632.1990.tb34288.x
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- Publication type:
- Article
Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity.
- Published in:
- Molecules, 2013, v. 18, n. 8, p. 8812, doi. 10.3390/molecules18088812
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- Publication type:
- Article
Synthesis of 5α-Androstane-17-spiro-δ-lactones with a 3-Keto, 3-Hydroxy, 3-Spirocarbamate or 3-Spiromorpholinone as Inhibitors of 17β-Hydroxysteroid Dehydrogenases.
- Published in:
- Molecules, 2013, v. 18, n. 1, p. 914, doi. 10.3390/molecules18010914
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- Publication type:
- Article
Preparation of 16β-Estradiol Derivative Libraries as BisubstrateInhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Using the Multidetachable Sulfamate Linker.
- Published in:
- Molecules, 2010, v. 15, n. 3, p. 1590, doi. 10.3390/molecules15031590
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- Publication type:
- Article
Aminosteroid RM-581 Decreases Cell Proliferation of All Breast Cancer Molecular Subtypes, Alone and in Combination with Breast Cancer Treatments.
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- Journal of Clinical Medicine, 2023, v. 12, n. 13, p. 4241, doi. 10.3390/jcm12134241
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- Article
Development of New Resolvin D1 Analogues for Osteoarthritis Therapy: Acellular and Computational Approaches to Study Their Antioxidant Activities.
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- Antioxidants, 2024, v. 13, n. 4, p. 386, doi. 10.3390/antiox13040386
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- Publication type:
- Article
Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model.
- Published in:
- Investigational New Drugs, 2019, v. 37, n. 3, p. 431, doi. 10.1007/s10637-018-0643-4
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- Article
In vitro evaluation of a tetrahydroisoquinoline derivative as a steroid sulfatase inhibitor and a selective estrogen receptor modulator.
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- Investigational New Drugs, 2015, v. 33, n. 1, p. 95, doi. 10.1007/s10637-014-0187-1
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- Publication type:
- Article
A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells.
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- Investigational New Drugs, 2012, v. 30, n. 1, p. 176, doi. 10.1007/s10637-010-9548-6
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- Publication type:
- Article
Raman and infrared spectra of crystalline 9-methyladenine and its methylmercury complexes.
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- Journal of Raman Spectroscopy, 1981, v. 11, n. 6, p. 481, doi. 10.1002/jrs.1250110611
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- Publication type:
- Article
Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer.
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- Journal of Molecular Cell Biology, 2015, v. 7, n. 6, p. 569, doi. 10.1093/jmcb/mjv028
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- Publication type:
- Article
Design of a Mestranol 2- N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models.
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- ChemMedChem, 2017, v. 12, n. 2, p. 177, doi. 10.1002/cmdc.201600482
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- Publication type:
- Article
Identification of a 17β-Hydroxysteroid Dehydrogenase Type 10 Steroidal Inhibitor: A Tool to Investigate the Role of Type 10 in Alzheimer's Disease and Prostate Cancer.
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- ChemMedChem, 2012, v. 7, n. 7, p. 1181, doi. 10.1002/cmdc.201200129
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- Publication type:
- Article
Synthesis of Libraries of 16β-Aminopropyl Estradiol Derivatives for Targeting Two Key Steroidogenic Enzymes.
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- ChemMedChem, 2006, v. 1, n. 11, p. 1249, doi. 10.1002/cmdc.200600071
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- Publication type:
- Article
Libraries of 2 β-( N-substituted piperazino)-5 α-androstane-3 α, 17 β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes.
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- Molecular Diversity, 2011, v. 15, n. 2, p. 317, doi. 10.1007/s11030-010-9273-2
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- Publication type:
- Article
Solid-phase synthesis of model libraries of 3 α17β-dihydroxy-16α-(aminoethyl-N-substituted)-5α-androstanes for the development of steroidal therapeutic agents.
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- Molecular Diversity, 2005, v. 9, n. 1-3, p. 67, doi. 10.1007/s11030-005-1312-z
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- Publication type:
- Article
New cancer drugs targeting the biosynthesis of estrogens and androgens.
- Published in:
- Drug Development Research, 2008, v. 69, n. 6, p. 304, doi. 10.1002/ddr.20263
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- Publication type:
- Article
A protectin DX (PDX) analog with in vitro activity against influenza A(H1N1) viruses.
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- Journal of Medical Virology, 2024, v. 96, n. 3, p. 1, doi. 10.1002/jmv.29484
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- Publication type:
- Article
17β‐hydroxysteroid dehydrogenase type 2 activity, expression and cellular localization in abdominal adipose tissues from women.
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- Clinical Endocrinology, 2023, v. 98, n. 2, p. 229, doi. 10.1111/cen.14838
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- Article
8-BuS-ATP derivatives as specific NTPDase1 inhibitors.
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- 2013
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- Publication type:
- journal article
8- BuS- ATP derivatives as specific NTPDase1 inhibitors.
- Published in:
- British Journal of Pharmacology, 2013, v. 169, n. 1, p. 179, doi. 10.1111/bph.12135
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- Publication type:
- Article
The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers.
- Published in:
- PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0144890
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- Publication type:
- Article
Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 20, p. 11181, doi. 10.3390/ijms222011181
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- Publication type:
- Article