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- Title
Genetic profile and characterization of antimicrobial resistance in Acinetobacter baumannii post-COVID-19 pandemic: a study in a tertiary hospital in Recife, Brazil.
- Authors
Rocha, Igor Vasconcelos; Martins, Lamartine Rodrigues; Pimentel, Maria Izabely Silva; Mendes, Renata Pessôa Germano; Lopes, Ana Catarina de Souza
- Abstract
Aims To investigate the genetic profile and characterize antimicrobial resistance, including the main β-lactam antibiotic resistance genes, in Acinetobacterbaumannii isolates from a tertiary hospital in Recife-PE, Brazil, in the post-COVID-19 pandemic period. Methods and Results Acinetobacter baumannii isolates were collected between 2023 and 2024 from diverse clinical samples. Antimicrobial resistance testing followed standardized protocols, with β-lactamase-encoding genes detected via PCR and sequencing. Investigation into ISAba1 upstream of bla OXA-carbapenemase and bla ADC genes was also conducted. Genetic diversity was assessed through ERIC-PCR. Among the 78 A. baumannii , widespread resistance to multiple antimicrobials was evident. Various acquired β-lactamase-encoding genes (bla OXA-23,-24,-58,-143, bla VIM, and bla NDM) were detected. Furthermore, this is the first report of bla VIM-2 in A. baumannii isolates harboring either the bla OXA-23-like or the bla OXA-143 gene in Brazil. Molecular typing revealed a high genetic heterogeneity among the isolates, and multi-clonal dissemination. Conclusion The accumulation of genetic resistance determinants underscores the necessity for stringent infection control measures and robust antimicrobial stewardship programs to curb multidrug-resistant strains.
- Subjects
RECIFE (Brazil); BRAZIL; GENETIC profile; DRUG resistance in microorganisms; ACINETOBACTER baumannii; COVID-19 pandemic; ANTIMICROBIAL stewardship
- Publication
Journal of Applied Microbiology, 2024, Vol 135, Issue 6, p1
- ISSN
1364-5072
- Publication type
Article
- DOI
10.1093/jambio/lxae148