We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Beyond the Usual Suspects: Examining the Role of Understudied Histone Variants in Breast Cancer.
- Authors
Dhahri, Hejer; Saintilnord, Wesley N.; Chandler, Darrell; Fondufe-Mittendorf, Yvonne N.
- Abstract
The incorporation of histone variants has structural ramifications on nucleosome dynamics and stability. Due to their unique sequences, histone variants can alter histone–histone or histone–DNA interactions, impacting the folding of DNA around the histone octamer and the overall higher-order structure of chromatin fibers. These structural modifications alter chromatin compaction and accessibility of DNA by transcription factors and other regulatory proteins to influence gene regulatory processes such as DNA damage and repair, as well as transcriptional activation or repression. Histone variants can also generate a unique interactome composed of histone chaperones and chromatin remodeling complexes. Any of these perturbations can contribute to cellular plasticity and the progression of human diseases. Here, we focus on a frequently overlooked group of histone variants lying within the four human histone gene clusters and their contribution to breast cancer.
- Subjects
BREAST cancer; HISTONES; DNA folding; REGULATOR genes; DNA condensation; TRANSCRIPTION factors; BREAST; DNA damage
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 12, p6788
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25126788