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- Title
The underlying mechanism of calcium toxicityinduced autophagic cell death and lysosomal degradation in early stage of cerebral ischemia.
- Authors
Sengking, Jirakhamon; Mahakkanukrauh, Pasuk
- Abstract
Cerebral ischemia is the important cause of worldwide disability and mortality, that is one of the obstruction of blood vessels supplying to the brain. In early stage, glutamate excitotoxicity and high level of intracellular calcium (Ca2+) are the major processes which can promote many downstream signaling involving in neuronal death and brain tissue damaging. Moreover, autophagy, the reusing of damaged cell organelles, is affected in early ischemia. Under ischemic conditions, autophagy plays an important role to maintain energy of the brain and its function. In the other hand, over intracellular Ca2+ accumulation triggers excessive autophagic process and lysosomal degradation leading to autophagic process impairment which finally induce neuronal death. This article reviews the association between intracellular Ca2+ and autophagic process in acute stage of ischemic stroke.
- Subjects
CEREBRAL ischemia; CELL death; ISCHEMIC stroke; CALCIUM; ORGANELLES; CALCIUM channels; GLUTAMATE receptors; CEREBRAL arteries
- Publication
Anatomy & Cell Biology, 2024, Vol 57, Issue 2, p155
- ISSN
2093-3665
- Publication type
Article
- DOI
10.5115/acb.24.003