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- Title
Novel antiepileptic drug levetiracetam decreases dyskinesia elicited by L-dopa and ropinirole in the MPTP-lesioned marmoset.
- Authors
Michael P. Hill; Erwan Bezard; Steven G. McGuire; Alan R. Crossman; Jonathan M. Brotchie; Ann Michel; Renee Grimée; Henrik Klitgaard
- Abstract
Long-term dopamine replacement therapy of Parkinson's disease leads to the occurrence of dyskinesias. Altered firing patterns of neurons of the internal globus pallidus, involving a pathological synchronization/desynchronization process, may contribute significantly to the genesis of dyskinesia. Levetiracetam, an antiepileptic drug that counteracts neuronal (hyper)synchronization in animal models of epilepsy, was assessed in the MPTPlesioned marmoset model of Parkinson's disease, after coadministration with (1) levodopa (L-dopa) or (2) ropinirole/L-dopa combination. Oral administration of levetiracetam (1360 mg/kg) in combination with either L-dopa (12 mg/kg) alone or L-dopa (8 mg/kg)/ropinirole (1.25 mg/kg) treatments was associated with significantly less dyskinesia, in comparison to L-dopa monotherapy during the first hour after administration. Thus, new nondopaminergic treatment strategies targeting normalization of abnormal firing patterns in basal ganglia structures may prove useful as an adjunct to reduce dyskinesia induced by dopamine replacement therapy without affecting its antiparkinsonian action. © 2003 Movement Disorder Society
- Subjects
DRUG therapy for Parkinson's disease; PARKINSON'S disease; DOPAMINE; MOVEMENT disorders; GLOBUS pallidus; ANTIPARKINSONIAN agents
- Publication
Movement Disorders, 2003, Vol 18, Issue 11, p1301
- ISSN
0885-3185
- Publication type
Article
- DOI
10.1002/mds.10542