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- Title
Radiogenomic correlation in lung adenocarcinoma with epidermal growth factor receptor mutations: Imaging features and histological subtypes.
- Authors
Hong, Su; Kim, Tae; Choi, Yo; Park, Jeong-Soo; Chung, Jin-Haeng; Lee, Kyung; Hong, Su Jin; Kim, Tae Jung; Choi, Yo Won; Lee, Kyung Won
- Abstract
<bold>Objectives: </bold>To correlate imaging features of resected lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation and the IASLC/ATS/ERS classification histological subtypes.<bold>Methods: </bold>In 250 consecutive patients with resected lung adenocarcinoma, EGFR mutation status was correlated with demographics, imaging features including ground-glass opacity (GGO) proportion and the IASLC/ATS/ERS classification histological subtypes.<bold>Results: </bold>EGFR mutations were significantly more frequent in women (54.5 % vs. 38.1 %, p = 0.011) and in never-smokers (54.7 % vs. 35.3 %, p = 0.003). GGO proportion was significantly higher in tumours with EGFR mutation than in those without (30.3 ± 33.8 % vs. 19.0 ± 29.3 %, p = 0.005). EGFR mutation was significantly more frequent in tumours with GGO ≥ 50 % and tumours with any GGO (p = 0.026 and 0.008, respectively). Adenocarcinomas with exon 19 or 21 mutation showed significantly higher GGO proportion than that in EGFR wild-type tumours (p = 0.009 and 0.029, respectively). Absence of GGO was an independent predictor of negative EGFR mutation (odds ratio, 1.81; 95 % confidence interval, 1.16-3.04; p = 0.018).<bold>Conclusions: </bold>GGO proportion in adenocarcinomas with EGFR mutation was significantly higher than that in EGFR wild-type tumours, and the absence of GGO on CT was an independent predictor of negative EGFR mutation.<bold>Key Points: </bold>• Ground-glass opacity (GGO) proportion is significantly higher in EGFR-mutated adenocarcinomas • Exon 19 or 21 mutated adenocarcinomas shows significantly higher GGO proportion • GGO absence is an independent predictor of negative EGFR mutation in lung adenocarcinomas.
- Subjects
LUNG cancer diagnosis; ADENOCARCINOMA; EPIDERMAL growth factor receptors; GENETIC mutation; HISTOPATHOLOGY; LUNG radiography; DIAGNOSIS
- Publication
European Radiology, 2016, Vol 26, Issue 10, p3660
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-015-4196-z