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- Title
Prostate diffusion-weighted imaging at 3T: effect of intravenous gadobutrol administration.
- Authors
Kim, Chan; Park, Jung; Park, Byung; Kim, Chan Kyo; Park, Jung Jae; Park, Byung Kwan
- Abstract
<bold>Objective: </bold>To investigate whether gadolinium-based contrast agent (GBCA) administration significantly affects diffusion-weighted imaging (DWI) at 3 T in the evaluation of prostate cancer and benign tissue.<bold>Method: </bold>Thirty-four consecutive patients with surgically proven prostate cancer underwent preoperative DWI at 3 T before and after GBCA administration. Exponential apparent diffusion coefficient (EADC) and ADC maps were developed from DWI data. The ADC and EADC values pre- and post-contrast were measured in the cancer and benign tissue, respectively. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were evaluated on pre- and post-contrast DWI.<bold>Results: </bold>The ADC and EADC values of the cancer and benign transition zone were not significantly different between pre- and post-contrast, respectively (P > 0.05), while those in the benign peripheral zone were significantly different (P = 0.030 and 0.037, respectively). In all tissues, the SNRs and CNRs of the DWI, ADC map and EADC map were not significantly different between pre- and post-contrast (P > 0.05). Between pre- and post-contrast, ADC and EADC values showed excellent agreement (intraclass correlation coefficient ≥ 0.894) and variability of ≤3.2 %.<bold>Conclusion: </bold>Prostate 3 T-DWI after GBCA administration may be used without a significant difference in SNR or CNR, with minimal variability of the cancer ADC and EADC values.<bold>Key Points: </bold>• ADCs and EADCs have excellent agreement before and after gadobutrol administration. • SNRs of prostate DWI are similar before and after gadobutrol administration. • CNRs of cancers are similar between pre- and post-contrast DWI.
- Subjects
PROSTATE; GADOLINIUM; DIFFUSION magnetic resonance imaging; PROSTATE cancer; SIGNAL-to-noise ratio; ANTHROPOMETRY; COMPARATIVE studies; INTRAVENOUS therapy; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; ORGANOMETALLIC compounds; PROSTATE tumors; RESEARCH; EVALUATION research; CONTRAST media; RETROSPECTIVE studies; DRUG administration; DRUG dosage
- Publication
European Radiology, 2016, Vol 26, Issue 5, p1450
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-015-3942-6