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- Title
Incidence of contrast-induced nephropathy in hospitalised patients with cancer.
- Authors
Cicin, Irfan; Erdogan, Bulent; Gulsen, Emrah; Uzunoglu, Sernaz; Sut, Necdet; Turkmen, Esma; Kodaz, Hilmi; Ustundag, Sedat
- Abstract
Objectives: To determine the frequency of and possible factors related to contrast-induced nephropathy (CIN) in hospitalised patients with cancer. Methods: Ninety adult patients were enrolled. Patients with risk factors for acute renal failure were excluded. Blood samples were examined the day before contrast-enhanced computed tomography (CT) and serially for 3 days thereafter. CIN was defined as an increase in serum creatinine (Cr) of 0.5 mg/dl or more, or elevation of Cr to 25 % over baseline. Relationships between CIN and possible risk factors were investigated. Results: CIN was detected in 18/90 (20 %) patients. CIN developed in 25.5 % patients who underwent chemotherapy and in 11 % patients who did not ( P = 0.1). CIN more frequently developed in patients who had undergone CT within 45 days after the last chemotherapy ( P = 0.005); it was also an independent risk factor ( P = 0.017). CIN was significantly more after treatment with bevacizumab/irinotecan ( P = 0.021) and in patients with hypertension ( P = 0.044). Conclusions: The incidence of CIN after CT in hospitalised oncological patients was 20 %. CIN developed 4.5-times more frequently in patients with cancer who had undergone recent chemotherapy. Hypertension and the combination of bevacizumab/irinotecan may be additional risk factors for CIN development. Key Points: • Contrast-induced nephropathy (CIN) is a concern for oncological patients undergoing CT. • CIN occurs more often when CT is performed <45 days after chemotherapy. • Hypertension and treatment with bevacizumab appear to be additional risk factors.
- Subjects
KIDNEY diseases; CANCER patients; HOSPITAL patients; TOMOGRAPHY; BEVACIZUMAB; IRINOTECAN; PHYSIOLOGICAL effects of chemotherapy
- Publication
European Radiology, 2014, Vol 24, Issue 1, p184
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-013-2996-6