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- Title
Distinguishing benign from malignant parotid gland tumours: low-dose multi-phasic CT protocol with 5-minute delay.
- Authors
Jin GQ; Su DK; Xie D; Zhao W; Liu LD; Zhu XN; Jin, G Q; Su, D K; Xie, D; Zhao, W; Liu, L D; Zhu, X N
- Abstract
<bold>Objectives: </bold>To explore the percentage enhancement wash-out ratio (PEW) and relative PEW (RPEW) of low-dose multi-phasic computed tomography (CT) in distinguishing benign from malignant parotid gland tumours.<bold>Methods: </bold>This study was approved by the ethics committee, and informed patient consent was obtained. 51 patients with parotid tumours proven by histopathology received CT, including 18 with pleomorphic adenomas, 14 with Warthin's tumours and 19 with malignant tumours. Size and attenuation of parotid tumours were measured. Compared with 5-min attenuation, the 30-s and 90-s PEW (PEW(30,) PEW(90)) and RPEW (RPEW(30), RPEW(90)) were calculated.<bold>Results: </bold>There was a significant difference in PEW(30), RPEW(30), PEW(90) and RPEW(90) in the parotid neoplasms groups (P < 0.01), and statistical significance existed simultaneously in pleomorphic adenomas vs malignant tumours and Warthin's tumours vs malignant tumours according to SNK-q test. The optimal diagnosis results of malignancy with 100% specificity (32/32) was obtained by using a combination of the following criteria: -70% > PEW(30) < 36%, -30% > PEW(30) < 19%, PEW(90) > 12%, and the sensitivity (74%) for diagnosis of malignancy was yield.<bold>Conclusions: </bold>Wash-out ratio may assist in differentiating the benign from malignant parotid gland tumours. Combining the percentage of enhanced wash-out ratios of CT protocols can yield diagnostic results for malignancy.
- Subjects
ADENOMA; ANALYSIS of variance; CANCER cells; COMPUTED tomography; DIFFERENTIAL diagnosis; PAROTID gland tumors; RADIATION doses; TIME; CONTRAST media; RECEIVER operating characteristic curves
- Publication
European Radiology, 2011, Vol 21, Issue 8, p1692
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-011-2101-y