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- Title
Pulmonary Langerhans cell histiocytosis in adults: high-resolution CT-pathology comparisons and evolutional changes at CT.
- Authors
Kim HJ; Lee KS; Johkoh T; Tomiyama N; Lee HY; Han J; Kim TS; Kim, Hyo Jin; Lee, Kyung Soo; Johkoh, Takeshi; Tomiyama, Noriyuki; Lee, Ho Yun; Han, Joungho; Kim, Tae Sung
- Abstract
<bold>Objective: </bold>To compare high-resolution (HR) CT and histopathological findings and to evaluate serial CT findings in pulmonary Langerhans cell histiocytosis (PLCH).<bold>Methods: </bold>We reviewed CT of lung lesions in 27 adults (M:F = 20:7, mean age, 41 ± 12.3 years) with PLCH. After evaluating lung abnormalities including nodules, micronodules, thick-walled, thin-walled, and bizarre-shaped cysts and reticulation, observers compared CT findings obtained at lung biopsy sites with histopathological findings. The final CT was compared with the initial CT to determine disease extent changes.<bold>Results: </bold>The most frequently observed patterns of lung abnormalities were micronodules (n = 24, 89%), thick-walled (n = 22, 82%), and thin-walled (n = 22, 82%) cysts. Even thin-walled and bizarre cysts harboured active inflammatory Langerhans cell sheets and eosinophils in their walls. In thin-walled cysts, we noted pericystic inflammatory cell infiltrations along the alveolar walls, as well as pericystic emphysema. Thin-walled or bizarre cysts demonstrated a tendency to coalesce with surrounding cysts via their cystic wall destruction. Fourteen (52%) patients showed improvement and nine (33%) showed progressing disease.<bold>Conclusion: </bold>More than half of patients with pulmonary PLCH show improvement at follow-up CT. Even thin-walled cysts harbour active inflammatory cells on histopathology and exhibit improvement at follow-up CT.
- Publication
European Radiology, 2011, Vol 21, Issue 7, p1406
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-011-2075-9