We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of -463G/A MPO gene polymorphism and risk of cervical intraepithelial neoplasia.
- Authors
Natter, Camilla; Polterauer, Stephan; Pils, Sophie; Castillo-Tong, Dan; Zeilinger, Robert; Heinze, Georg; Hefler, Lukas; Grimm, Christoph; Castillo-Tong, Dan Cacsire
- Abstract
<bold>Purpose: </bold>The MPO system plays an important role in the control of infections and the deletion of malignant cells. Nevertheless, alternations in the MPO system can lead to DNA damage and carcinogenesis. Polymorphisms in the MPO Gene have been associated with an increased expression of MPO and a higher risk for development of cancer. This study evaluates the association between -463G/A MPO gene polymorphism and the risk for CIN.<bold>Methods: </bold>The MPO gene polymorphism (-463G/A) was investigated in 616 women with cervical intraepithelial neoplasia and in 206 healthy women. Association between MPO gene polymorphism and risk of cervical intraepithelial neoplasia were analyzed by univariate and multivariable models.<bold>Results: </bold>No significant difference in genotype distribution of the MPO gene polymorphism was observed in women with CIN and controls (p = 0.4; OR 1.2, 95 % CI 0.8-1.6). A subgroup analysis only including women with CIN did not show an association between -463G/A MPO gene polymorphism and risk for high-grade CIN (CIN 2/3) (p = 0.09; OR 1.5, 95 % CI 0.9-2.3).<bold>Conclusions: </bold>The investigated MPO gene polymorphism is not associated with risk for the development of cervical intraepithelial neoplasia.
- Subjects
CERVICAL intraepithelial neoplasia; GENETIC polymorphisms; MYELOPEROXIDASE; DNA damage; CARCINOGENESIS; DISEASE risk factors; DISEASE susceptibility; OXIDOREDUCTASES; POLYMERASE chain reaction; WHITE people; CERVIX uteri tumors; CASE-control method; GENOTYPES
- Publication
Archives of Gynecology & Obstetrics, 2016, Vol 293, Issue 4, p865
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s00404-015-3869-9