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- Title
Association of interleukin-6 in women with persistence of DNA-HPV: a nested case-control study.
- Authors
Rosa, Maria; Moraes, Matheus; Vuolo, Francieli; Petronilho, Fabricia; Bozzetti, Mary; Medeiros, Lidia; Igansi, Cristine; Silva, Fábio; Dal-Pizzol, Felipe; Rosa, Daniela
- Abstract
Objective: To identify the role of Interleukin-6, IL-10 and their epidemiological association in women with persistence of DNA-HPV. Design and methods: A nested case-control study within a longitudinal cohort study. Cervical specimens and blood samples were collected at enrolment from asymptomatic women who looked for a service of public health in a district of Porto Alegre, Brazil. A logistic regression analysis was performed with 95% confidence intervals. The outcome was the persistence of DNA-HPV infection. Results: The analysis showed that the age of the first intercourse below 20 years old (OR = 19.65, IC 95% 2.43-68.85), four or more sexual partners during lifetime (OR = 5.67, IC 95% 1.28-24.99), women with a previous altered Pap smear (OR = 10.17, IC 95% 1.80-57.33), marital status (OR = 12.94, IC 95% 2.43-68.85) and IL6 ≤ 3.106 pg/ml were associated with persistence of HPV infection. IL-10 were not associated with the HPV persistence. Conclusion: The present study suggests that IL-6 levels may be a marker of HPV DNA persistence, although further investigation is necessary.
- Subjects
CERVICAL cancer; PAPILLOMAVIRUS diseases; INTERLEUKIN-6; EPIDEMIOLOGY; LOGISTIC regression analysis; DNA; CANCER in women; BIOMARKERS
- Publication
Archives of Gynecology & Obstetrics, 2012, Vol 285, Issue 1, p143
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-011-1925-7