We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome Category IIIA with Serenoa repens plus Selenium and Lycopene (Profluss®) versus S. repens Alone: An Italian Randomized Multicenter-Controlled Study.
- Authors
Morgia, G.; Mucciardi, G.; Galì, A.; Madonia, M.; Marchese, F.; Benedetto, A. Di; Romano, G.; Bonvissuto, G.; Castelli, T.; Macchione, L.; Magno, C.
- Abstract
Objectives: To evaluate the efficacy and safety of Serenoa repens + selenium and lycopene (Profluss®) versus S. repens alone for the treatment of category IIIa chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Patients and Methods: 102 patients with IIIa CP/CPPS were enrolled and randomized into two groups each to receive Profluss or S. repens alone for 8 weeks. Evaluation was based on results of the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), IPSS, maximum peak flow rate (MPFR), and PSA measurements at baseline and at weeks 4, 8 and 8 after the end of treatment. The primary endpoint was a >50% reduction in NIH-CPSI score. Secondary endpoints evaluated were MPFR, IPSS, PSA and white blood cell count. Results: No patients withdrew from the study. The mean NIH-CPSI score decreased significantly (p < 0.001) in both groups; we observed a decrease in the total score from 27.45 to 13.27 in group 1 (–51.64%) and from 27.76 to 20.62 in group 2 (–26.06%). IPSS improved significantly (p < 0.001) in both arms, but more in group 1. PSA and white blood cell count decreased significantly (p < 0.007) only in group 1. The MPFR improved more in group 1 (p < 0.005). Conclusion: Profluss is a triple therapy that is safe and well tolerated. It ameliorates symptoms associated with IIIa CP/CPPS. Copyright © 2010 S. Karger AG, Basel
- Subjects
SELENIUM; LYCOPENE; SAW palmetto; PROSTATITIS; PELVIC pain; BLOOD cell count; THERAPEUTICS
- Publication
Urologia Internationalis, 2010, Vol 84, Issue 4, p400
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000302716