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- Title
Insights into potential cellular mechanisms of cisplatin nephrotoxicity and their clinical application.
- Authors
Kuhlmann, M K; Burkhardt, G; Köhler, H
- Abstract
Cisplatin preferentially accumulates in cells of the S3 segment of the renal proximal tubule and is toxified intracellularly by hydration. The earliest manifestation of toxicity is inhibition of protein synthesis. GSH depletion is another important mechanism causing CP toxicity. Intracellular binding to SH groups leads to GSH depletion, resulting in lipid peroxidation and eventually mitochondrial damage. New measures to prevent GSH depletion and scavenge intracellular free oxygen radicals have been tried in clinical studies. Promising results indicate that cisplatin nephrotoxicity can be further reduced in the future.
- Publication
Nephrology Dialysis Transplantation, 1997, Vol 12, Issue 12, p2478
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/12.12.2478