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- Title
Cefoperazone versus cefamandole in the treatment of acute bacterial lower respiratory tract infections.
- Authors
File, Thomas M.; Tan, James S.; Gardner, William G.; Baird, Ian; File, T M Jr; Tan, J S; Gardner, W G; Baird, I
- Abstract
In a randomized comparative study, 113 patients were treated with cefoperazone or cefamandole for acute bacterial lower respiratory tract infections. Most patients had Streptococcus pneumoniae or Haemophilus influenzae infections, although five patients in the cefoperazone group had infections caused by other Gram-negative bacilli (two with Pseudomonas aeruginosa). The clinical responses and adverse effects were not significantly different between the two treatment groups. Satisfactory clinical responses occurred in 36/39 (92%) of evaluable patients in the cefoperazone group and 33/34 (97%) of evaluable patients treated with cefamandole. Two failures in the cefoperazone group were secondary to superinfection (Acinetobacter and Ps. aeruginosa). Bacteriological and symptomatic failure occurred in one patient with Ps. aeruginosa lung abscess treated with cefoperazone and in one patient with a polymicrobial empyema treated with cefamandole. The results of this study indicate that cefoperazone is safe and effective in the therapy of acute bacterial lower respiratory tract infections.
- Subjects
CEFOPERAZONE; CEPHALOSPORINS; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; MICROBIAL sensitivity tests; RESEARCH; RESPIRATORY infections; STATISTICAL sampling; EVALUATION research; RANDOMIZED controlled trials; ACUTE diseases; THERAPEUTICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1983, Vol 11, Issue 1, p75
- ISSN
0305-7453
- Publication type
journal article