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- Title
The effects of pearl oyster shell-derived bone grafts on TNF-alfa levels: An in vivo study in Cavia porcellus.
- Authors
Oktawati, Sri; Hamrun, Nurlindah; Muthmainnah, Muthmainnah; Setiawati, Dian; Yusuf, Andi Sitti Hajrah
- Abstract
Objective: This study aims to assess the effect of bone graft materials derived from pearl oyster shells on the tumor necrosis factor-alpha (TNF-α) level. Methods: This research utilized a bone graft containing hydroxyapatite Pinctada maxima (HPM) powder obtained from pearl oyster shells. Material testing was conducted on 30 male guinea pigs aged 8-10 weeks, divided into three groups: the negative control group, the group treated solely with HPM, and the group treated with HPM combined with platelet-rich fibrin (PRF). Each treatment group was observed for 7 and 14 days. The results were analyzed using One-way ANOVA with a significance level of p<0.05. Results: The findings demonstrated a decrease in the average TNF-α levels across all groups. On observation days 7 and 14, the HPM group exhibited a significant difference compared to the negative control group, indicating reduced TNF-α levels. However, no significant difference was observed when comparing the HPM group with the HPM and PRF groups. Conclusions: Bone grafts derived from pearl oyster shells possess high levels of hydroxyapatite, and the addition of PRF into the bone graft effectively reduces TNF-α.
- Subjects
GUINEA pigs; PLATELET-rich fibrin; DATA analysis; T-test (Statistics); BONE regeneration; PERIODONTAL disease; IN vivo studies; INVERTEBRATES; BONE grafting; ANIMAL experimentation; ONE-way analysis of variance; STATISTICS; DATA analysis software; TUMOR necrosis factors
- Publication
Acta Marisiensis. Seria Medica, 2024, Vol 70, Issue 2, p68
- ISSN
2668-7755
- Publication type
Article
- DOI
10.2478/amma-2024-0015