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- Title
Ligand‐promoted dehydrogenative coupling of γ‐/β‐amino alcohols with ketones to N‐heterocycles via molybdenum catalysts.
- Authors
Wang, Yuanyuan; Ma, Ning; Yan, Xiuli; Li, Libin; Lin, Qing; Han, Peng; Zhao, Bin; Mahmood, Qaiser; Liu, Qingbin; Wang, Zheng
- Abstract
Molybdenum‐based efficient and broadly applicable catalytic system is presented for the dehydrogenative coupling of γ‐/β‐amino alcohols with ketones. In particular, complex Mo(CO)6 in combination with Xantphos and t‐BuOK as base provides direct synthesis of structurally diverse quinoline, pyridine, and pyrrole compounds (total 55 examples) with isolated yields up to 92%. Low catalyst loading, cost‐effective, and high catalytic activities with high tolerance to stand with diverse functional groups are additional features of these molybdenum catalysts exhibiting high efficacy to replace the precious metal catalysts such as ruthenium and iridium. Furthermore, the DFT and experimental studies were explored for the reaction mechanism which can assist in broadening the scope of the molybdenum catalysts for different transformation reactions.
- Subjects
MOLYBDENUM catalysts; IRIDIUM catalysts; METAL catalysts; KETONES; CATALYTIC activity; AMINO alcohols; RUTHENIUM catalysts; QUINOLINE
- Publication
Applied Organometallic Chemistry, 2024, Vol 38, Issue 6, p1
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.7480