We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Novobiocin-ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition.
- Authors
Mbaba, Mziyanda; de la Mare, Jo-Anne; Sterrenberg, Jason N.; Kajewole, Deborah; Maharaj, Shantal; Edkins, Adrienne L.; Isaacs, Michelle; Hoppe, Heinrich C.; Khanye, Setshaba D.
- Abstract
Abstract: A series of tailored novobiocin-ferrocene conjugates was prepared in moderate yields and investigated for in vitro anticancer and antiplasmodial activity against the MDA-MB-231 breast cancer line and Plasmodium falciparum 3D7 strain, respectively. While the target compounds displayed moderate anticancer activity against the breast cancer cell line with IC50 values in the mid-micromolar range, compounds 10a-c displayed promising antiplasmodial activity as low as 0.889 µM. Furthermore, the most promising compounds were tested for inhibitory effects against a postulated target, heat shock protein 90 (Hsp90).Graphical abstract: A selection of tailored novobiocin derivatives bearing the organometallic ferrocene unit were synthesized and characterized by common spectroscopic techniques. The target compounds were investigated for in vitro anticancer and antimalarial activity against the MDA-MB-231 breast cancer cell line and Plasmodium falciparum 3D7 strain, respectively.
- Subjects
NOVOBIOCIN; FERROCENE; HEAT shock proteins; ANTINEOPLASTIC agents; ANTIMALARIALS; BREAST cancer treatment
- Publication
Journal of Biological Inorganic Chemistry (JBIC), 2019, Vol 24, Issue 2, p139
- ISSN
0949-8257
- Publication type
Article
- DOI
10.1007/s00775-018-1634-9