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- Title
Divergent mechanisms of iron-containing enzymes for hydrocarbon biosynthesis.
- Authors
Wise, Courtney; Grant, Job; Amaya, Jose; Ratigan, Steven; Hsieh, Chun; Manley, Olivia; Makris, Thomas
- Abstract
Increasing levels of energy consumption, dwindling resources, and environmental considerations have served as compelling motivations to explore renewable alternatives to petroleum-based fuels, including enzymatic routes for hydrocarbon synthesis. Phylogenetically diverse species have long been recognized to produce hydrocarbons, but many of the enzymes responsible have been identified within the past decade. The enzymatic conversion of C chain length fatty aldehydes (or acids) to C hydrocarbons, alkanes or alkenes, involves a C-C scission reaction. Surprisingly, the enzymes involved in hydrocarbon synthesis utilize non-heme mononuclear iron, dinuclear iron, and thiolate-ligated heme cofactors that are most often associated with monooxygenation reactions. In this review, we examine the mechanisms of several enzymes involved in hydrocarbon biosynthesis, with specific emphasis on the structural and electronic changes that enable this functional switch. Graphical abstract:
- Subjects
ENERGY consumption; IRON catalysts; HYDROCARBON synthesis; CARBON-carbon bonds; OXYGENATION (Chemistry)
- Publication
Journal of Biological Inorganic Chemistry (JBIC), 2017, Vol 22, Issue 2/3, p221
- ISSN
0949-8257
- Publication type
Article
- DOI
10.1007/s00775-016-1425-0