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- Title
复合植物精油对产气荚膜梭菌感染肉鸡 生长性能和免疫功能的影响.
- Authors
李 倩; 宁 楠; 谌 梦; 徐欢欢; 王 蕾; 丁斌鹰; 侯永清; 郭双双
- Abstract
This experiment was conducted to investigate the effects of compound plant essential oil on growth performance and intestinal health of broilers challenged by Clostridium perfringens. A total of 288 one day-old Ross 308 broilers were randomly divided into four groups, which were control group, C. per⁃ fringens-infected group, infection + compound plant essential oil CTA (100 mg/kg) group, and infection + compound plant essential oil CAT (100 mg/kg) group, with 6 replicates in each group. The CTA and CAT was obtained by mixing thymol, cinnam⁃ aldehyde and anisaldehyde at the ratios of 1:3: 1 and 1:1:3, respectively. The experimental pe⁃ riod lasted for 42 days. The broiler chickens were infected by infusion of 1 mL of 1×108 CFU/mL C. perfringens solution from 15 to 21 d. The result showed that compared with the control group, the infected group decreased the feed intake (P=0.093), sig⁃ nificantly decreased villus height, increased crypt depth, significantly up- regulated the mRNA expres⁃ sion of interleukin-8 (IL-8) in jejunum at 21 days of age (P<0.05), significantly up-regulated the mRNA expression of (iNOS), IL-8 and tumor necrosis factor-α (TNF-α) in spleen at 21 days of age, and signifi⁃ cantly up-regulated the mRNA expression of IL-8 in cecum tonsil at 28 days of age; compared with the infected group, the infection+CTA and infection+CAT groups significantly increased the villus height and villus crypt ratio, significantly up-regulated the mRNA expression of Toll-like receptor-2 (TLR2), Tolllike receptor-4 (TLR4), interleukin-1β (IL-1β), and IL-8 mRNA in jejunum at 21 days of age (P<0.05), and significantly increased the mRNA expression of TLR2, TLR4, IL-1β, tumor necrosis factor-α (TNFα), interleukin-13 (IL-13), interferon- γ (IFN- γ), and transforming growth factor- β4 in jejunum at 28 days (P<0.05), significantly down regulated the mRNA expression of IL-8 in cecum tonsil at 28 days (P<0.05). The infection+CTA group significantly down regulated the mRNA expression of iNOS, TNF-α and IL-1β in spleen at 21 days and significantly up-regulated the mRNA expression of immunoglobulin A (IgA)、IL-13 in jejunum and serum IgA levels at 28 days of age (P<0.05). In conclusion, the addition of compound plant essential oil to the diet could improve digestion and absorption capacity and regulate inflammation to alleviate the immune responses of broilers intestine and spleen by C. perfringens. The ad⁃ dition of compound plant essential oil CTA showed superior effects.
- Publication
Feed Industry, 2023, Vol 44, Issue 13, p57
- ISSN
1001-991X
- Publication type
Article
- DOI
10.13302/j.cnki.fi.2023.13.008