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- Title
Polimorfismo P.D1134A del gen TJP1 en población con ancestría zapoteca; potencial marcador para cáncer de tiroides y otras neoplasias.
- Authors
Madrigal-Ruiz, P.; Dávalos-Rodríguez, N. O.; Ramírez-García, S. A.; Topete-González, L. R.; Mazariegos-Rubi, M.; Flores-Alvarado, L. J.; Ruiz-Mejia, R.; Aguilar-Aldrete, M. E.; Magallanes-Ordoñez, J. J.; Ramón-Canul, L. G.; Siliceo-Murrieta, J. I.; Zurita-Vásquez, G. G.; Cruz-Bastida, J. M.
- Abstract
Introduction. TJP1 gene encodes protein ZO-1, that is required for the recruitment of occludins and claudins in tight junctions involved in cell polarization. It has different variations that have been studied in several populations. There are no studies regarding this gene in Mexico. It is necessary to continue investigation because its polymorphisms may be used in association studies for thyroid cancer and other neoplasms. Considering its expression level, an increase in ZO-1 has been demonstrated in thyroid medullar cancer. The objective of this study is to estimate the frequency of genotypes and alleles of polymorphism rs 2291166 (p.D1134A) in gene TJP1 among Mexican population with Zapotec ancestry. Material and Methods. 159 individuals with Zapotec ancestry were included. The polymorphism was identified by PCR-PASA and electrophoresis PAGE 7%.. Results. The most frequent allele in both populations was ancestral allele (T), as in other populations. The polymorphism is in Hardy-Weinberg equilibrium among the population analyzed (p >0.05). Discussion. SNP rs2291166 is a polymorphic marker in Mexican population and it may be used in association studies regarding thyroid carcinogenesis.
- Publication
Revista Médica MD, 2015, Vol 7, Issue 1, p21
- ISSN
2007-8188
- Publication type
Article