We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sensorineural Impairments, Cardiovascular Risk Factors, and 10-Year Incidence of Cognitive Impairment and Decline in Midlife: The Beaver Dam Offspring Study.
- Authors
Schubert, Carla R; Cruickshanks, Karen J; Fischer, Mary E; Pinto, A Alex; Chen, Yanjun; Huang, Guan-Hua; Klein, Barbara E K; Klein, Ronald; Pankow, James S; Paulsen, Adam J; Dalton, Dayna S; Tweed, Ted S
- Abstract
<bold>Background: </bold>Sensorineural impairments and cardiovascular risk factors (CVRF) and disease (CVD) in midlife may be important predictors of future cognitive health, but longitudinal studies that include multiple sensorineural measures in middle-aged adults are lacking.<bold>Methods: </bold>Hearing, vision, and olfaction, and CVRF and CVD were measured at the Beaver Dam Offspring Study baseline (2005-2008) examination. The Mini-Mental State Examination and Trail Making Tests A and B were administered at all phases and additional cognitive function measures were obtained at 5 (2010-2013) and 10 years (2015-2017). Cox proportional hazards models were used to evaluate associations between baseline sensorineural impairments, CVRF, CVD, and 10-year cumulative incidence of cognitive impairment and decline.<bold>Results: </bold>There were 2,556 participants (22-84 years) without cognitive impairment at baseline and data from at least one follow-up. In a multivariable model including age, sex, education, and head injury, visual impairment (hazard ratio = 2.59, 95% confidence interval = 1.34, 5.02), olfactory impairment (hazard ratio = 3.18, 95% confidence interval = 1.53, 6.59), CVD (hazard ratio = 2.37, 95% confidence interval = 1.24, 4.52), and not consuming alcohol in the past year (hazard ratio = 2.21, 95% confidence interval = 1.16, 4.19) were associated with the 10-year cumulative incidence of cognitive impairment. Current smoking and diabetes were associated with increased risk, and exercise with decreased risk, of 10-year decline in cognitive function.<bold>Conclusions: </bold>Visual and olfactory impairments, CVRF, and CVD were associated with the 10-year cumulative incidence of cognitive impairment and decline in middle-aged adults. Identifying modifiable factors associated with cognitive decline and impairment in midlife may provide opportunities for prevention or treatment and improve cognitive health later in life.
- Subjects
MINI-Mental State Examination; TRAIL Making Test; MIDDLE-aged persons; CARDIOVASCULAR diseases risk factors; SENSORY disorders; COGNITION disorders
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2019, Vol 74, Issue 11, p1786
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glz011