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- Title
A Comparison of Two Mouse Frailty Assessment Tools.
- Authors
Kane, Alice E.; Huizer-Pajkos, Aniko; Mach, John; Mitchell, Sarah J.; de Cabo, Rafael; Le Couteur, David G.; Howlett, Susan E.; Hilmer, Sarah N.
- Abstract
The mouse clinical frailty index and the mouse frailty phenotype assessment are two recently developed tools used to assess frailty in mice. The objectives of this study were to investigate whether the same mice are identified as frail with both tools and to examine the association of each of the assessment tools with age and frailty-related outcomes. Frailty was measured using both tools in old (~24 months; n = 36) C57BL/6 male mice. After 2 weeks, blood pressure and heart rate were measured and serum samples were collected for analysis of alanine aminotransferase, creatinine, and albumin levels. The mouse frailty phenotype assessment identified no mice as frail but modification of the assessment tool identified six mice as frail. The mouse clinical frailty index identified 16 mice as frail and the agreement between the two scales was 50.0%. Increasing clinical frailty index scores were correlated with low serum alanine aminotransferase, as well as decreased heart rate, and reduced heart rate variance. We conclude that, consistent with equivalent frailty assessment scales in humans, both tools have value but do not necessarily identify the same mice as frail.
- Subjects
FRAGILITY (Psychology); AGING; BLOOD pressure; HEART beat; BLOOD serum analysis; LABORATORY mice; GERIATRIC assessment; ANIMAL experimentation; BIOLOGICAL models; FRAIL elderly; HEALTH status indicators; MEDICAL care research; MICE; MOTOR ability; PHYSICAL fitness
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2017, Vol 72, Issue 7, p904
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glx009