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- Title
Serum Ionized Magnesium.
- Authors
Resnick, Lawrence M; Bardicef, Orit; Altura, Bella T; Alderman, Michael H; Altura, Burton M
- Abstract
To study potential ionic factors predisposing to vascular disease in hypertension, particularly among black subjects, we used a recently developed combined magnesium and calcium specific, ion selective electrode apparatus to measure extracellular ionized calcium (Ca-ion), ionized magnesium (Mg-ion), and Ca-ion/Mg-ion ratios in the serum of fasting, nonmedicated white and black normotensive (n = 61) and hypertensive (n = 23) subjects, studied consecutively in a tertiary referral center.Both race and blood pressure status had independent effects on the distribution of Mg-ion values. Although Mg-ion levels for the group as a whole were lower in hypertensive versus in normotensive subjects (0.571 ± 0.012 v 0.601 ± 0.005 mmol/L; P < .01), this was only true of white subjects (0.579 ± 0.021 v 0.620 ± 0.006 mmol/L; P = .0095). The lack of a significant difference in Mg-ion levels between black hypertensive versus normotensive subjects (0.553 ± 0.012 v 0.577 ± 0.007 mmol/L, P = NS) was attributable to the significantly lower Mg-ion levels present in normotensive blacks compared to those in normotensive white subjects (0.577 ± 0.007 v 0.620 ± 0.006 mmol/L, P = .0001). Resultant Ca-ion/Mg-ion ratios were elevated in all black subjects and in white hypertensive subjects.These data support the presence among hypertensives and among black subjects (independently of blood pressure) of a consistent depletion of circulating magnesium and of an imbalance of calcium and magnesium that may potentiate vascular disease among these subjects.Am J Hypertens (1997) 10, 1420-1424; doi: S0895-7061(97)00364-6
- Publication
American Journal of Hypertension, 1997, Vol 10, Issue 12, p1420
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(97)00364-6