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- Title
Effect of daily tramadol administration on sperm indices and morphology of testes in rabbits.
- Authors
Emokpae, Mathias A.; Femi-Idris, Oluwakemi; Onuyoh-Adaitire, Blessing
- Abstract
Introduction: Tramadol is an effective analgesic used in the treatment of mild to severe pains, but unregulated use may cause deleterious effects on the reproductive system of males. Objective: The objective of this study was to evaluate the effect of graded doses and duration of Tramadol on sperm indices and histomorphology of testes in male rabbits. Method: This is an experimental study of 24 male rabbits, divided into eight groups of three rabbits in each group. The rabbits were administered 10, 15, and 20 mg/kg daily doses of Tramadol intramuscularly for 15 and 30 days while F and G received intramuscular Tramadol of 10 and 20 mg/kg daily respectively for 15 days and were left to recover for 15 days. Group H received physiological saline only and served as the control group. Rabbits in each group were sacrificed and the caudal epididymis was excised from the rabbits for semen analysis. The left testes were removed for histological examinations. Results: The sperm motility, viability, and count were significantly lower (p<0.001), while sperm head abnormality was higher (p<0.001) with increasing concentrations and duration of Tramadol administration. There was no significant difference in semen pH. Upon withdrawal and recovery, sperm motility, viability, and count returned to near those of control rabbits. However, the differences in sperm head abnormality and semen pH were not significant compared with control rabbits. The germinal epithelium of the seminiferous tubules showed disturbance in the spermatogenic layers, with the reduced number of sperms and hypertrophic Leydig cells in the recovery Tramadol group, reduced number of Leydig cells and wide inter-tubular spaces in the chronic Tramadol group. Conclusion: The study indicated the harmful and damaging effects of Tramadol administration on the reproductive system of rabbits. It is suggested that the use of Tramadol should be regulated and dose monitored to prevent its deleterious effects on male fertility potential.
- Subjects
TRAMADOL; DRUG administration; PAIN management; SPERM motility; LABORATORY rabbits
- Publication
Manipal Journal of Nursing & Health Sciences, 2022, Vol 8, Issue 2, p45
- ISSN
2395-1397
- Publication type
Article
- DOI
10.55889/2582-7979.1262