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- Title
Mutation ofFADDgene is rare in human colon and stomach cancers.
- Authors
Young Hwa Jong; Jong Woo Lee; Su Young Kim; Suk Woo Nam; Won Sang Park; Sang Ho Kim; Jung Young Lee; Nam Jin Yoo; Sug Hyung Lee
- Abstract
Soung YH, Lee JW, Kim SY, Nam SW, Park WS, Kim SH, Lee JY, Yoo NJ, Lee SH. Mutation of FADD gene is rare in human colon and stomach cancers. APMIS 2004;112:595–7.Failure of apoptosis is one of the hallmarks of cancer. As an adaptor, FADD plays a crucial role during death receptor-mediated apoptosis. We previously reported that theFADDgene is somatically mutated in non-small cell lung cancers. To explore the possibility that the genetic alterations of theFADDgene might be involved in the development of other human cancers, we analyzed the entire coding region and all splice sites of the humanFADDgene to detect somatic mutations in 116 stomach cancers and 98 colon cancers. Overall, we detected a somatic missense mutation of theFADDgene in a colon carcinoma, which was predicted to change an amino acid (R140H) in the death domain (DD) of the FADD protein. This is the first report ofFADDgene mutation in gastrointestinal cancers, and our data suggest that theFADDgene is rarely mutated in human colon and stomach cancers.
- Subjects
GENETIC mutation; ANTIBODY diversity; GENETICS; APOPTOSIS; STOMACH cancer; COLON cancer
- Publication
APMIS, 2004, Vol 112, Issue 9, p595
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/j.1600-0463.2004.apm1120906.x