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- Title
Emotional Problems, Quality of Life and Symptom Burden in Patients with Chordoma.
- Authors
Wu, Youtu; Li, Chuzhong; Zhang, Huifang; Wang, Guoqin; Jing, Linkai; Yi, Guo; Yang, Xuejun; Gui, Songbai; Gao, Hua; Zhang, Yazhuo; Wang, Guihuai; Bai, Jiwei
- Abstract
Chordomas are very rare malignant bone tumors. Following surgery, their effects on neurological, physical, psychological, social, and emotional functioning are substantial and can have a major impact on a patients' quality of life (QOL). In this survey, we aimed to characterize the postoperation health-related QOL and emotional problem in patients with chordoma using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30) and Hamilton Depression Rating Scale (HAMD). The cohort included 100 patients who underwent resection surgery between 2014 and 2020. Being single or divorced, living in a rural area, receiving a diagnosis of sacrococcygeal chordoma, Karnofsky performance status (KPS) ≤ 70, and weight loss were associated with increased likelihood of depression (p < 0.05). Patients who were single or divorced, with KPS ≤ 70, and experiencing weight loss had a higher likelihood of a worse QOL (p < 0.05). The uni- and multivariate logistic regression analyses indicated that the KPS level (p = 0.000) and postoperative radiation therapy (p = 0.009) were related to depression; marital status (p = 0.029), KPS level (p = 0.006), and tumor location (p = 0.033) were related to worse QOL. Certain characteristics placed patients with chordoma at increased risk of emotional problems, which are associated with a lowered QOL and a higher symptom burden. Further knowledge regarding emotional problems is key to improving the QOL for patients with chordoma.
- Subjects
CHINA; MENTAL depression risk factors; GERM cell tumors; CANCER patient psychology; MULTIPLE regression analysis; SURGERY; PATIENTS; POPULATION geography; BONE tumors; RISK assessment; QUALITY of life; AFFECTIVE disorders; RESEARCH funding; QUESTIONNAIRES; KARNOFSKY Performance Status; MARITAL status; SYMPTOMS
- Publication
Healthcare (2227-9032), 2023, Vol 11, Issue 8, p1135
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare11081135